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Plant and Cell Physiology Advance Access published online on March 3, 2005
Plant and Cell Physiology, doi:10.1093/pcp/pci082
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Plant and Cell Physiology 2005 © The Japanese Society of Plant Physiologists (JSPP); all rights reserved.
Received November 15, 2004
Accepted February 18, 2005

Regular Paper

TONSOKU Is Expressed in S Phase of the Cell Cycle and Its Defect Delays Cell Cycle Progression in Arabidopsis

Takamasa Suzuki 1*, Sakiko Nakajima 1, Soichi Inagaki 1, Makiko Hirano-Nakakita 1, Ken Matsuoka 2, Taku Demura 2, Hiroo Fukuda 2, Atsushi Morikami 3, and Kenzo Nakamura 1

1 Laboratory of Biochemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
2 Plant Science Center, RIKEN (The Institute of Physical and Chemical Research), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
3 Faculty of Agriculture, Meijo University, Tenpaku-ku, Nagoya 468-8502, Japan

* To whom correspondence should be addressed.
Takamasa Suzuki, E-mail: i992009d{at}mbox.nagoya-u.ac.jp


  Abstract

The TONSOKU(TSK)/MGOUN3/BRUSHY1 of Arabidopsis thaliana is a nuclear leucine-glycine-aspargine (LGN) domain protein implicated to be involved in the genome maintenance, and mutants with defects in TSK show fasciated stem with disorganized meristem structures. We identified a homolog of TSK from tobacco BY-2 cells (NtTSK), which showed high sequence conservation both in the LGN domain and leucine-rich repeats with AtTSK. The NtTSK gene was expressed during S phase of the cell cycle in tobacco BY-2 cells highly synchronized for cell division. The tsk mutants of Arabidopsis contained increased proportion of cells with 4C nuclei and cells expressing cyclin B1 compared to the wild type. These results suggest that TSK is required during the cell cycle and defects of TSK cause the arrest of cell cycle progression at G2/M phase.

Keywords: Arabidopsis; cell cycle; G2 checkpoint; genome maintenance; TONSOKU/MGOUN3/BRUSHY1.
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