Plant and Cell Physiology Advance Access originally published online on March 3, 2005
Plant and Cell Physiology 2005 46(5):736-742; doi:10.1093/pcp/pci082
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TONSOKU is Expressed in S Phase of the Cell Cycle and its Defect Delays Cell Cycle Progression in Arabidopsis
1 Laboratory of Biochemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601 Japan
2 Plant Science Center, RIKEN (The Institute of Physical and Chemical Research), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 Japan
3 Faculty of Agriculture, Meijo University, Tenpaku-ku, Nagoya, 468-8502 Japan
4 Corresponding author: E-mail, takamasa{at}thaliana.myhome.cx; Fax, +81-52-789-2966.
TONSOKU(TSK)/MGOUN3/BRUSHY1 of Arabidopsis thaliana encodes a nuclear leucine–glycine–aspargine (LGN) domain protein implicated to be involved in genome maintenance, and mutants with defects in TSK show a fasciated stem with disorganized meristem structures. We identified a homolog of TSK from tobacco BY-2 cells (NtTSK), which showed high sequence conservation both in the LGN domain and in leucine-rich repeats with AtTSK. The NtTSK gene was expressed during S phase of the cell cycle in tobacco BY-2 cells highly synchronized for cell division. The tsk mutants of Arabidopsis contained an increased proportion of cells with 4C nuclei and cells expressing cyclin B1 compared with the wild type. These results suggest that TSK is required during the cell cycle and defects of TSK cause the arrest of cell cycle progression at G2/M phase.
5 Present address: Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, 464-8602 Japan.
(Received November 15, 2004; Accepted February 18, 2005
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