Plant and Cell Physiology, 2001, Vol. 42, No. 2 107-113
© 2001 Oxford University Press
Paper |
The Arabidopsis Sensor His-kinase, AHK4, Can Respond to Cytokinins
Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya, 464-8601 Japan
Abstract
His-to-Asp (His
Asp) phosphorelay mechanisms are presumably involved in propagation of certain environmental stimuli, including phytohormones, in Arabidopsis thaliana. In addition to the previously characterized His-kinases, namely, the ETR1 family of ethylene receptors, CKI1 cytokinin-sensor, and ATHK1 osomo-sensor, this higher plant has three more His-kinases (named AHK2, AHK3, and AHK4). By employing the well-known HisAsp phosphorelay systems in both the fission yeast and Escherichia coli, evidence is presented showing that the AHK4 His-kinase has an ability to serve as a cytokinin-responsive environmental sensor. Taking advantage of this AHK4-dependent HisAsp phosphorelay system in E. coli, a phosphorelay interaction between the Arabidopsis His-kinase and histidine-containing phosphotransmitters (AHPs) was also demonstrated for the first time.
Footnotes
1 These two authors equally contributed to this work.
2 Corresponding author: E-mail, tmizuno@agr.nagoya-u.ac.jp; Fax, +81-52-789-4089.
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|
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|
|
|
|
|
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|
|
|
|
|
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|
|
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|
|
|
|
|
|
J. Sheen Phosphorelay and Transcription Control in Cytokinin Signal Transduction Science, May 31, 2002; 296(5573): 1650 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
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|
|
|
|
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|
|
|
|
|
|
G. Haberer and J. J. Kieber Cytokinins. New Insights into a Classic Phytohormone Plant Physiology, February 1, 2002; 128(2): 354 - 362. [Full Text] [PDF]
|
|
|
|
|
|
J. Lohrmann and K. Harter Plant Two-Component Signaling Systems and the Role of Response Regulators Plant Physiology, February 1, 2002; 128(2): 363 - 369. [Full Text] [PDF]
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|