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Plant and Cell Physiology 2004 45(11):1715-1719; doi:10.1093/pcp/pch184
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© 2004 Oxford University Press

Short Communication

Ectopic Expression of the NtSET1 Histone Methyltransferase Inhibits Cell Expansion, and Affects Cell Division and Differentiation in Tobacco Plants

Wen-Hui Shen1 and Denise Meyer

Institut de Biologie Moléculaire des Plantes (IBMP), Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur de Strasbourg (ULP), 12 rue du Général Zimmer, 67084 Strasbourg Cédex, France

Abstract

The tobacco NtSET1 gene encodes a member of the SUV39H family of histone methyltransferases. Ectopic expression of NtSET1 causes an increase in methylated histone H3 lysine 9 and abnormal chromosome segregation in tobacco suspension cells, and inhibits tobacco plant growth. Here we show that the inhibition of plant growth was caused by reduced cell expansion as well as by abnormal cell division and differentiation. We found that deletion of the C-terminally located catalytic domain of the protein abolished the ectopic effects of NtSET1 on plant growth. Our results indicate that histone H3 lysine 9 methylation is a critical mark of epigenetic control for plant development.

Footnotes

1 Corresponding author: E-mail, Wen-Hui.Shen{at}ibmp-ulp.u-strasbg.fr; Fax, +33-3-88-61-44-42.


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