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Plant and Cell Physiology, 1985, Vol. 26, No. 2 379-382
© 1985

Short Communication

Inhibition of Porphobilinogen Synthase Activity by 4,5-Dioxovalerate

Yuzo Shioi, Michio Doi and Tsutomu Sasa

Division of Biology, Miyazaki Medical College Kiyotake, Miyazaki 889-16, Japan

The effect of 4,5-dioxovaleric acid on the activity of porphobilinogen (PBG) synthase (formerly 5-aminolevulinic acid dehydratase, EC 4.2.1.24 [EC] ) of the porphyrin synthetic pathway was studied with the enzyme purified from Chlorella regularis. 4,5-Dioxovaleric acid, a metabolite of 5-aminolevulinic acid, competitively inhibited PBG synthase with a Ki value of 1.4 mM. The concentration for the half inhibition of 4,5-dioxovaleric acid (7 mM) was slightly lower than that for the known competitive inhibitor, levulinic acid (12 mM).

(Received October 8, 1984; Accepted December 13, 1984)
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